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THE DIGGLE LAB
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Lab mission
We are based in the Center for Microbial Dynamics and Infection (part of the School of Biological Sciences) at Georgia Tech in Atlanta.

Our primary objective is to gain a deeper understanding of microbial interactions and social behaviors, with a focus on their impact on virulence, antimicrobial resistance (AMR), and the development of therapeutic strategies. We predominantly investigate the antibiotic-resistant superbug, Pseudomonas aeruginosa, which the CDC has classified as a 'critical threat' within healthcare environments.

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Main research areas
  • Elucidating the role of R-pyocins (bacteriocins) in strain competition and as a therapeutic strategy to combat multi-drug-resistant P. aeruginosa.
  • Genomic and phenotypic heterogeneity of P. aeruginosa populations within chronic infections and the implications for virulence, biofilm formation and antimicrobial resistance.
  • Mechanistic and evolutionary aspects of quorum sensing in P. aeruginosa.
  • ​Understanding cooperation and conflict within bacterial populations (social evolution) and how we can exploit this to treat infections.​​​
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