R-pyocins are phage tail-like bacteriocin nanomachines produced by P. aeruginosa specifically to target and kill other strains of P. aeruginosa. We are focused on understanding the role of R-pyocins in strain competition and exploring their potential as therapeutic agents.

High prevalence of lipopolysaccharide mutants and R2-pyocin susceptible variants in Pseudomonas aeruginosa populations sourced from cystic fibrosis lung infections.
Mei M, Pheng P, Kurzeja-Edwards D, Diggle SP.

Heterogenous Susceptibility to R-Pyocins in Populations of Pseudomonas aeruginosa Sourced from Cystic Fibrosis Lungs.
Mei M, Thomas J, Diggle SP.

Competition in Biofilms between Cystic Fibrosis Isolates of Pseudomonas aeruginosa Is Shaped by R-Pyocins.
Oluyombo O, Penfold CN, Diggle SP.