Publications
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Gurney, J., Azimi, S., Brown, S. P. & Diggle, S. P. (2020) Combinatorial quorum sensing in Pseudomonas aeruginosa allows for novel cheating strategies. Microbiology (early online).
Vanderwoude, J., Fleming, D., Azimi, S., Trivedi, U., Rumbaugh, K. P. & Diggle, S. P. (2020) The evolution of virulence in Pseudomonas aeruginosa during chronic wound infection. bioRxiv pre-print.
Azimi, S., Klementiev, A. D., Whiteley, M. & Diggle, S. P. (2020) Bacterial quorum sensing during infection. Annual Review of Microbiology (in press).
Azimi, S., Roberts, A. E. L., Peng, S., Weitz, J. S., McNally, A., Brown, S. P. & Diggle, S. P. (2020) Allelic polymorphism shapes community function in evolving Pseudomonas aeruginosa populations. ISME J (early online).
Diggle, S. P. & Whiteley, M. (2020) Pseudomonas aeruginosa: opportunistic pathogen and lab rat. Microbiology. 166: 30-33.
Chiba, A., Bawaneh, A., Velazquez, C., Clear, K. Y., Wilson, A. S., Howard-McNatt, M., Levine, E. A., Levi-Polyachenko, N., Yates-Alston, S. A., Diggle, S. P., Soto-Pantoja, D. R. & Cook, K. L. (2020). Neoadjuvant chemotherapy shifts breast tumor microbiota populations to regulate drug responsiveness and the development of metastasis. Molecular Cancer Research. 18: 130-139.
Oluyombo, O., Penfold, C.N. & Diggle, S. P. (2019) Competition in biofilms between cystic fibrosis isolates of Pseudomonas aeruginosa is influenced by R-pyocins. mBio. 10: e01828-18.
Thomas, J. & Diggle, S. P. (2019) The social evolution of bacterial quorum sensing. Encyclopedia of Microbiology, Academic Press. 423-427.
Fletcher M. P., Diggle S. P., Cámara M. & Williams P. (2018) Detection of 2-alkyl-4-quinolones using biosensors. Methods in Molecular Biology. 1673: 25-34.
Garge, S., Azimi, S. & Diggle, S. P. (2018) A simple mung bean infection model for studying the virulence of Pseudomonas aeruginosa. Microbiology. 164: 764-768.
Whiteley, M., Diggle, S. P. & Greenberg, E. P. (2017) Progress in and promise of bacterial quorum sensing research. Nature. 551: 313-320.
Harrison, F., McNally, A., Da Silva, A., Heeb, S. & Diggle, S. P. (2017) Optimised chronic infection models demonstrate that siderophore ‘cheating’ in Pseudomonas aeruginosa is context specific. ISME J. 11: 2942-2509.
Davies, S. K., Fearn, S., Allsopp, L. P., Harrison, F., Ware, E., Diggle, S. P., Filloux, A., McPhail, D. S. & Bundy, J. G. (2017) Visualizing Antimicrobials in Bacterial Biofilms: Three-Dimensional Biochemical Imaging Using TOF-SIMS. mSphere. 4: e00211-17.
Irie, Y., Roberts, A. E. L., Kragh, K. N., Gordon, V. D., Hutchison, J., Allen, R. J., Melaugh, G., Bjarnsholt, T., West, S. A. & Diggle, S. P. (2017) The Pseudomonas aeruginosa PSL polysaccharide is a social but non-cheatable trait in biofilms. mBio. 8: e00374-17
Pollitt, E. J. G. & Diggle, S. P. (2017) Defining motility in the Staphylococci. Cellular and Molecular Life Sciences. 74: 2943-2958.
Mund, A., Diggle, S. P. & Harrison, F. (2017) The fitness of Pseudomonas aeruginosa quorum sensing signal cheats is influenced by the diffusivity of the environment. mBio. 8: e00353-17.
Popat, R., Harrison, F., Da Silva, A., Easton, S., McNally, L., Williams, P. & Diggle, S. P. (2017) Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production. Proc Soc. 284: 20170200.
Moreau, P., Diggle, S. P. & Friman, V. P. (2017) Bacterial cell-to-cell signalling promotes the evolution of resistance to parasitic bacteriophages. Ecology & Evolution. 7: 1936-1941.
Harrison, F. & Diggle, S. P. (2016) An ex vivo lung model to study bronchioles infected with Pseudomonas aeruginosa biofilms. Microbiology. 162: 1755-1760.
Ruparell, A., Dubern, J. F., Ortori, C. A., Harrison, F., Halliday, N. M., Emtage, A., Laughton, C., Diggle, S. P., Williams, P., Barrett, D. A. & Hardie, K. R. (2016) The fitness burden imposed by synthesising quorum sensing signals. Scientific Reports. 6: 33101.
Kragh, K. N., Hutchison, J. B., Melaugh, G., Rodesney, C., Roberts, A. E. L., Irie, Y., Jensen, P. O., Diggle, S. P., Allen, R. J., Gordon, V. & Bjarnsholt, T. (2016) Role of multicellular aggregates in biofilm formation. mBio. 7: e00237-16.
Melaugh,G., Hutchison, J., Kragh, K., Irie, Y., Roberts, A., Bjarnsholt, T., Diggle, S. P., Gordon, V. & Allen, R. (2016) Shaping the growth behaviour of biofilms initiated from bacterial aggregates. PLOS ONE. 11: e0149683.
Pollitt, E. J. G., Crusz, S. A. & Diggle, S. P. (2015) Staphylococcus aureus forms spreading dendrites that have characteristics of active motility. Scientific Reports. 5: 17698.
Roberts, A. E. L., Kragh, K., Bjarnsholt, B. & Diggle, S. P. (2015) The limitations of in vitro experimentation in understanding biofilms and chronic infection. Journal of Molecular Biology. 427: 3646-3661.
Popat, R., Pollitt, E. J. G., Griffin, A. S., Williams, P., Brown, S. P., West, S. A. & Diggle, S. P. (2015) Conflict of interest and signal interference lead to the breakdown of honest signalling. Evolution. 69: 2371-2383.
Harrison, F., Roberts, A. E. L., Gabrilska, R., Rumbaugh, K. P., Lee, C. & Diggle, S. P. (2015) A 1000 year old antimicrobial remedy with anti-Staphylococcal activity. mBio. 6:e01129-15.
Darch, S. E., McNally, A., Harrison, F., Corander, J., Barr, H. L., Paszkiewicz, K., Holden, S., Fogarty, A., Crusz, S. A. & Diggle, S. P. (2015) Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection. Scientific Reports. 5: 7649.
Laabei, M., Jamieson, W. D., Diggle, S. P. & Jenkins, A. T. A. (2014) A new assay for rhamnolipid detection-important virulence factors of Pseudomonas aeruginosa. Applied Microbiology & Biotechnology. 98: 7199-7209.
Harrison, F., Muruli, A. Higgins, S. & Diggle, S. P. (2014) Development of an ex vivo porcine lung model for studying growth, virulence and signalling in Pseudomonas aeruginosa populations. Infection & Immunity. 82: 3312-3323.
Scott-Phillips, T., Gurney, J., Ivens, A. Diggle, S. P. & Popat, R. (2014) Combinatorial communication in bacteria: Implications for the origins of linguistic generativity. PLOS ONE. 9: e95929.
Cornforth, D. M., Popat, R., McNally, L., Gurney, J., Scott-Phillips, T., Diggle, S. P. & Brown, S. P. (2014) Combinatorial quorum sensing allows bacteria to resolve their social and physical environment. Proceedings of the National Academy of Sciences USA. 111: 4280-4284.
Allen, R. C., Popat, R., Diggle, S. P. & Brown, S. P. (2014) Targeting virulence: Can we make evolution-proof drugs? Nature Reviews Microbiology. 12: 300-308.
Ghoul, M., West, S. A., Diggle, S. P. & Griffin, A. S. (2014) An experimental test of whether cheating is context-dependent. Journal of Evolutionary Biology. 27: 551-556.
Pollitt, E. J. G., West, S. A., Crusz, S. A., Burton-Chellew, M. N. & Diggle, S. P. (2014) Cooperation, quorum sensing and the evolution of virulence in Staphylococcus aureus. Infection & Immunity. 82: 1045-1051.
Jiricny, N., Molin, S., Foster, K., Diggle, S. P., Scanlan, P. D., Ghoul, M., Santorelli, L., Popat, R., West, S. A. & Griffin, A. S. (2014) Loss of social behaviours in populations of Pseudomonas aeruginosa infecting lungs of patients with cystic fibrosis. PLOS ONE. 9: e83124.
Schuster, M., Sexton, D. J., Diggle, S. P. & Greenberg, E. P. (2013) Acyl-homoserine lactone quorum sensing: From evolution to application. Annual Review of Microbiology. 67: 43-63.
Friman, V.P., Diggle, S. P. & Buckling, A. (2013) Protist predation can favour cooperation within bacterial species. Biology Letters. 9: 20130548.
West, S. A., Winzer, K., Gardner, A. & Diggle, S. P. (2012) Quorum sensing and the confusion about diffusion. Trends in Microbiology. 20: 586-594.
Popat, R., Crusz, S. A., Messina, M., Williams, P., West, S. A. & Diggle, S. P. (2012) Quorum sensing and cheating in bacterial biofilms. Proceedings of the Royal Society B. 279: 4765-4771.
Crusz. S. A., Popat, R., Rybtke, M. T., Camara, M., Givskov, M., Nielsen, T. T., Diggle, S. P. & Williams, P. (2012) Bursting the bubble on bacterial biofilms: a flow cell methodology. Biofouling. 28: 835-842.
Youle, M., Rohwer, F., Whiteley, M., Steel, B. C., Delalez, N. J., Nord, A. L., Berry, R. M., Armitage, J. P., Kamoun, S., Hogenhout, S., Diggle, S. P., Gurney, J., Pollitt, E. J. G., Boetius, A. and Cary, S. C. (2012) The pathogen relay. In Microbial Olympics, Nature Reviews Microbiology. 10: 583-588.
Rumbaugh, K. P., Trivedi, U., Watters, C., Burton-Chellew, M., Diggle, S. P. & West, S. A. (2012) Kin selection, quorum sensing and virulence in pathogenic bacteria. Proceedings of the Royal Society B. 279: 3584-2588.
Darch, S. E., West, S. A., Winzer, K. & Diggle, S. P. (2012) Density-dependent fitness benefits in quorum sensing bacterial populations. Proceedings of the National Academy of Sciences USA. 109: 8259-8263.
Stacy, A. R., Diggle, S. P. & Whiteley, M. (2012) Rules of engagement: defining bacterial communication. Current Opinion in Microbiology. 15: 155-161.
Goldstone, R., Popat, R., Fletcher, M. P., Crusz, S. A. & Diggle, S. P. (2012) Quorum sensing and social interactions in microbial biofilms. In Microbial Biofilms: current research, methods and applications (ed. Gillian Lewis). Horizon Scientific Press.
Diggle, S. P. & Williams, P. (2012) Quorum sensing. In Brenners Encyclopedia of Genetics (ed. Maloy & Hughes).
Johansson, E. M. V., Kadam, R. U., Rispoli, G., Crusz, S. A., Bartels, K., Diggle, S. P., Cámara, M., Williams, P., Jaeger, K. E., Darbre, T. & Reymond, J. L. (2011) Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids. Medicinal Chemistry Communications. 5: 418-420.
Wilder, C. N., Diggle, S. P. & Schuster, M. (2011) Cooperation and cheating in Pseudomonas aeruginosa: the roles of the las, rhl and pqs quorum-sensing systems. ISME J. 5: 1332-1343.
Liu, X., Jia, J., Popat, R., Ortori, C. A., Li, J., Diggle, S. P., Cámara, M. & Gao, K. (2011) Characterisation of two quorum sensing systems in the endophytic Serratia plymuthica strain G3: differential control of motility and biofilm formation according to life-style. BMC Microbiology. 11: 26.
Heeb, S., Fletcher, M. P., Chhabra, S. R., Diggle, S. P., Williams, P. & Camara, M. (2011) Quinolones: from antibiotics to autoinducers. FEMS Microbiology Reviews. 35: 247-274.
Diggle, S. P., Fletcher, M. P., Camara, M. & Williams, P. (2011) Detection of 2-alkyl-4-quinolones using biosensors. Methods in Molecular Biology. 692: 21-30.
Diggle, S. P. (2010) Microbial communication and virulence: lessons from evolutionary theory. Microbiology. 156: 3503-3512.
Jiricny, N., Diggle, S. P., West, S. A., Evans, B. A., Ballantyne, G., Ross-Gillespie, A. & Griffin, A. S. (2010) Fitness correlates with the extent of cheating in a bacterium. Journal of Evolutionary Biology. 23: 738-747.
Fletcher, M. P., Heeb, S., Chhabra, S. R., Diggle, S. P., Williams, P. & Camara, M. (2010) 2-alkyl-4-quinolone signalling in Pseudomonas aeruginosa. In Pseudomonas vol VI: Molecular Microbiology, Infection & Biodiversity (ed. Alain Filloux & Juan Ramos). Springer Press.
Brown, S. P., West, S. A., Diggle, S. P., Griffin, A. S. (2009) Social evolution in microorganisms and a trojan horse approach to medical intervention strategies. Philosophical Transactions of the Royal Society B. 364: 3157-3168.
Zaborin, A., Long, J., Holbrook, C. Gerdes, S., Diggle, S. P., Rhigetti, K., Lepine, F., Wilke, A., Morozova, I., Liu, D. C., Zaborina, O. & Alverdy, J. C. (2009) Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1. Proceedings of the National Academy of Sciences USA. 106: 6327-6332.
Skindersoe, M. E., Zeuthen, L. H., Brix, S., Fink, L. N., Lazenby, J., Whittall, C., Williams, P., Diggle, S. P., Froekiaer, H., Cooley, M. & Givskov, M. (2009) Pseudomonas aeruginosa quorum sensing signal molecules interfere with dendritic cell induced T cell proliferation. FEMS Immunology and Medical Microbiology. 55: 335-345.
Rumbaugh, K. P., Diggle, S. P., Watters, C., Ross-Gillespie, A., Griffin, A. S., & West, S. A. (2009) Quorum sensing and the social evolution of bacterial virulence. Current Biology. 19: 341-345.
Johansson, E., Crusz, S. A., Kolomiets, E., Buts, L., Kadam, R. U., Cacciarini, M., Bartels, K. M., Diggle, S. P., Camara, M., Williams, P., Loris, R., Nativi, C., Rosenau, F., Jaeger, K. E., Dabre, T. & Reymond, J. L. (2008) Inhibition and dispersion of Pseudomonas aeruginosa biofilms by glycopeptide dendrimers targeting the fucose-specific lectin LecB. Chemistry and Biology. 15: 1249-1257.
Popat, R., Crusz, S. A. & Diggle, S. P. (2008) The social behaviours of bacterial pathogens. British Medical Bulletin. 87: 63-75.
Dubern, J. F. & Diggle, S. P. (2008) Quorum sensing signaling by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species. Molecular Biosystems. 4: 882-888.
von Bodman, S. B., Willey, J. M. & Diggle, S. P. (2008) Cell-to-cell communication in bacteria: united we stand. Journal of Bacteriology. 190: 4377-4391. (Review on the 3rd cell-to-cell communication in bacteria meeting held in Austin Texas in 2007).
Romero, M., Diggle, S. P., Heeb, S., Camara, M. & Otero, A. (2008) Quorum quenching activity in Anabaena sp. PCC 7120: identification of AiiC, a novel AHL-acylase. FEMS Microbiology Letters. 280: 73-80.
Diggle, S. P., West, S. A., Gardner, A. & Griffin, A. S. (2008) Communication in bacteria. In Sociobiology of communication: An interdisciplinary perspective (ed. David Hughes & Patrizia D'Ettorre): pp. 11-31. Oxford University Press.
Diggle, S. P., Heeb, S., Dubern, J. F., Fletcher, M. P., Crusz, S. A., Camara, M. & Williams, P. (2008) Quorum sensing in Pseudomonas. In Pseudomonas: Model organism, pathogen, cell factory (ed. Bernd Rehm): pp. 167-194. Wiley-VCH, Weinheim, Germany.
Diggle, S. P., Griffin, A. S., Campbell, G. S. & West S. A. (2007) Cooperation & conflict in quorum sensing bacterial populations. Nature. 450: 411-414.
Diggle, S. P., Crusz, S. A. & Camara, M. (2007) Quorum sensing. Current Biology. 17: R907-R910.
Fletcher, M. P., Diggle, S. P., Crusz, S. A., Chhabra, S. R., Camara, M. & Williams, P. (2007) A dual biosensor for 2-alkyl-4-quinolone quorum sensing signal molecules. Environmental Microbiology. 9: 2683-2693.
West, S. A., Diggle, S. P., Buckling, A. Gardner, A. & Griffin, A. S. (2007) The social lives of microbes. Annual Review of Ecology, Evolution and Systematics. 38: 53-77.
Diggle, S. P., Gardner, A., West, S. A. & Griffin, A. S. (2007) Evolutionary theory of bacterial quorum sensing: When is a signal not a signal? Philosophical Transactions of the Royal Society B. 362: 1241-1249.
Fletcher, M. P., Diggle, S. P., Camara, M. & Williams, P. (2007) Biosensor-based assays for PQS, HHQ and related 2-alkyl-4-quinolone quorum sensing signal molecules. Nature Protocols. 2: 1254-1262.
Diggle, S. P., Matthijs, S., Wright, V. J., Fletcher, M. P., Chhabra, S. R., Lamont, I. L., Kong, X., Hider, R. C., Cornelis, P., Camara, M. & Williams, P. (2007) The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multi-functional roles in quorum sensing and iron entrapment. Chemistry & Biology. 14: 87-96.
Holden, M. T. G., Diggle, S. P. & Williams, P. (2007) Quorum sensing. In Encyclopedia of Life Sciences. John Wiley & Sons.
Lumjiaktase, P., Diggle, S. P., Loprasert, S., Tungpradabkul, S., Daykin, M., Camara, M., Williams, P. & Kunakorn, M. (2006) Quorum sensing regulates dpsA and the oxidative stress response in Burkholderia pseudomallei. Microbiology. 152: 3651-3659.
Diggle, S. P., Lumjiaktase, P., Dipilato, F., Winzer, K., Kunakorn, M., Barrett, D., Chhabra, S. R., Camara, M. & Williams, P. (2006) Functional genetic analysis reveals a 2-alkyl-4-quinolone signaling system in the human pathogen Burkholderia pseudomallei and related bacteria. Chemistry & Biology. 13: 701-710.
West, S. A., Griffin, A. S., Gardner, A & Diggle, S. P. (2006) Social evolution theory for microorganisms. Nature Reviews Microbiology. 4: 597-607.
Diggle, S. P., Stacey, R. E., Dodd, C., Camara, M., Williams, P. & Winzer. K. (2006) The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa. Environmental Microbiology. 8: 1095-1104.
Sio, C. F., Otten, L. G., Cool, R. H., Diggle, S. P., Braun, P. G., Bos, R., Daykin, M., Williams, P. & Quax, W. (2006) Quorum quenching by an N-acyl homoserine lactone acylase of Pseudomonas aeruginosa PAO1. Infection & Immunity. 74: 1673-1682.
Diggle, S. P., Cornelis, P., Williams, P. & Camara, M. (2006) 4-Quinolone signalling in Pseudomonas aeruginosa: Old molecules, new perspectives. International Journal of Medical Microbiology. 296: 83-91.
Krasnogor, N., Gheorghe, M., Terrazas, G., Diggle, S. P., Williams, P. & Camara, M. (2005) An appealing computational mechanism drawn from bacterial quorum sensing. Bulletin of the European Association for Theoretical Computer Science. 83: 135-148.
Aendekerk, S., Diggle, S. P., Song, Z., Hoiby, N., Cornelis, P., Williams, P. and Camara, M. (2005) The MexGHI-OpmD multidrug efflux pump controls fitness, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication. Microbiology. 151: 1113-1125.
Terrazas, G., Krasnogor, N., Georghe, M., Bernardini, F., Diggle, S. P. & Camara, M. (2005) An environment aware P-system model of quorum sensing. In: New Computational Paradigms. Book series: Lecture Notes in Computer Science. 3526: 479-485. Springer Berlin/Heidelberg.
Westfall, L. W., Luna, A. M., Francisco, M. S., Diggle, S. P., Worrall, K. E., Williams, P., Camara, M. and Hamood, A. N. (2004) The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression. Microbiology. 150: 3797-3806.
Vallet, I., Diggle, S. P., Stacey, R. E., Camara, M., Ventre, I., Lory, S., Lazdunski, A., Williams, P. & Filloux, A. (2004) Biofilm formation in Pseudomonas aeruginosa: Fimbrial cup gene clusters are controlled by the transcriptional regulator MvaT. Journal of Bacteriology. 186: 2880-2890.
Diggle, S. P., Winzer, K., Chhabra, S. R., Worrall, K. E., Camara, M. & Williams, P. (2003) The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR. Molecular Microbiology. 50: 29-43.
Pritchard, D., Hooi, D., Watson, E., Chow, S., Telford, G., Bycroft, B., Chhabra, S. R., Harty, C., Camara, M., Diggle, S. P., & Williams, P. (2003) Bacterial quorum sensing signalling molecules as immune modulators. In Bacterial evasion of host immune responses (ed. B. Henderson & P. Oyston): pp. 201-221. Cambridge University Press.
Diggle, S. P., Winzer, K., Lazdunski, A., Williams, P. & Camara, M. (2002) Advancing the quorum in Pseudomonas aeruginosa: MvaT and the regulation of N-acylhomoserine lactone production and virulence gene expression. Journal of Bacteriology. 184: 2576-2586.
Winzer, K., Falconer, C., Garber, N. C., Diggle, S. P., Camara, M. & Williams, P. (2000) The Pseudomonas aeruginosa lectins PA-IL and PA-IIL are controlled by quorum sensing and by RpoS. Journal of Bacteriology. 182: 6401-6411.
Vanderwoude, J., Fleming, D., Azimi, S., Trivedi, U., Rumbaugh, K. P. & Diggle, S. P. (2020) The evolution of virulence in Pseudomonas aeruginosa during chronic wound infection. bioRxiv pre-print.
Azimi, S., Klementiev, A. D., Whiteley, M. & Diggle, S. P. (2020) Bacterial quorum sensing during infection. Annual Review of Microbiology (in press).
Azimi, S., Roberts, A. E. L., Peng, S., Weitz, J. S., McNally, A., Brown, S. P. & Diggle, S. P. (2020) Allelic polymorphism shapes community function in evolving Pseudomonas aeruginosa populations. ISME J (early online).
Diggle, S. P. & Whiteley, M. (2020) Pseudomonas aeruginosa: opportunistic pathogen and lab rat. Microbiology. 166: 30-33.
Chiba, A., Bawaneh, A., Velazquez, C., Clear, K. Y., Wilson, A. S., Howard-McNatt, M., Levine, E. A., Levi-Polyachenko, N., Yates-Alston, S. A., Diggle, S. P., Soto-Pantoja, D. R. & Cook, K. L. (2020). Neoadjuvant chemotherapy shifts breast tumor microbiota populations to regulate drug responsiveness and the development of metastasis. Molecular Cancer Research. 18: 130-139.
Oluyombo, O., Penfold, C.N. & Diggle, S. P. (2019) Competition in biofilms between cystic fibrosis isolates of Pseudomonas aeruginosa is influenced by R-pyocins. mBio. 10: e01828-18.
Thomas, J. & Diggle, S. P. (2019) The social evolution of bacterial quorum sensing. Encyclopedia of Microbiology, Academic Press. 423-427.
Fletcher M. P., Diggle S. P., Cámara M. & Williams P. (2018) Detection of 2-alkyl-4-quinolones using biosensors. Methods in Molecular Biology. 1673: 25-34.
Garge, S., Azimi, S. & Diggle, S. P. (2018) A simple mung bean infection model for studying the virulence of Pseudomonas aeruginosa. Microbiology. 164: 764-768.
Whiteley, M., Diggle, S. P. & Greenberg, E. P. (2017) Progress in and promise of bacterial quorum sensing research. Nature. 551: 313-320.
Harrison, F., McNally, A., Da Silva, A., Heeb, S. & Diggle, S. P. (2017) Optimised chronic infection models demonstrate that siderophore ‘cheating’ in Pseudomonas aeruginosa is context specific. ISME J. 11: 2942-2509.
Davies, S. K., Fearn, S., Allsopp, L. P., Harrison, F., Ware, E., Diggle, S. P., Filloux, A., McPhail, D. S. & Bundy, J. G. (2017) Visualizing Antimicrobials in Bacterial Biofilms: Three-Dimensional Biochemical Imaging Using TOF-SIMS. mSphere. 4: e00211-17.
Irie, Y., Roberts, A. E. L., Kragh, K. N., Gordon, V. D., Hutchison, J., Allen, R. J., Melaugh, G., Bjarnsholt, T., West, S. A. & Diggle, S. P. (2017) The Pseudomonas aeruginosa PSL polysaccharide is a social but non-cheatable trait in biofilms. mBio. 8: e00374-17
Pollitt, E. J. G. & Diggle, S. P. (2017) Defining motility in the Staphylococci. Cellular and Molecular Life Sciences. 74: 2943-2958.
Mund, A., Diggle, S. P. & Harrison, F. (2017) The fitness of Pseudomonas aeruginosa quorum sensing signal cheats is influenced by the diffusivity of the environment. mBio. 8: e00353-17.
Popat, R., Harrison, F., Da Silva, A., Easton, S., McNally, L., Williams, P. & Diggle, S. P. (2017) Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production. Proc Soc. 284: 20170200.
Moreau, P., Diggle, S. P. & Friman, V. P. (2017) Bacterial cell-to-cell signalling promotes the evolution of resistance to parasitic bacteriophages. Ecology & Evolution. 7: 1936-1941.
Harrison, F. & Diggle, S. P. (2016) An ex vivo lung model to study bronchioles infected with Pseudomonas aeruginosa biofilms. Microbiology. 162: 1755-1760.
Ruparell, A., Dubern, J. F., Ortori, C. A., Harrison, F., Halliday, N. M., Emtage, A., Laughton, C., Diggle, S. P., Williams, P., Barrett, D. A. & Hardie, K. R. (2016) The fitness burden imposed by synthesising quorum sensing signals. Scientific Reports. 6: 33101.
Kragh, K. N., Hutchison, J. B., Melaugh, G., Rodesney, C., Roberts, A. E. L., Irie, Y., Jensen, P. O., Diggle, S. P., Allen, R. J., Gordon, V. & Bjarnsholt, T. (2016) Role of multicellular aggregates in biofilm formation. mBio. 7: e00237-16.
Melaugh,G., Hutchison, J., Kragh, K., Irie, Y., Roberts, A., Bjarnsholt, T., Diggle, S. P., Gordon, V. & Allen, R. (2016) Shaping the growth behaviour of biofilms initiated from bacterial aggregates. PLOS ONE. 11: e0149683.
Pollitt, E. J. G., Crusz, S. A. & Diggle, S. P. (2015) Staphylococcus aureus forms spreading dendrites that have characteristics of active motility. Scientific Reports. 5: 17698.
Roberts, A. E. L., Kragh, K., Bjarnsholt, B. & Diggle, S. P. (2015) The limitations of in vitro experimentation in understanding biofilms and chronic infection. Journal of Molecular Biology. 427: 3646-3661.
Popat, R., Pollitt, E. J. G., Griffin, A. S., Williams, P., Brown, S. P., West, S. A. & Diggle, S. P. (2015) Conflict of interest and signal interference lead to the breakdown of honest signalling. Evolution. 69: 2371-2383.
Harrison, F., Roberts, A. E. L., Gabrilska, R., Rumbaugh, K. P., Lee, C. & Diggle, S. P. (2015) A 1000 year old antimicrobial remedy with anti-Staphylococcal activity. mBio. 6:e01129-15.
Darch, S. E., McNally, A., Harrison, F., Corander, J., Barr, H. L., Paszkiewicz, K., Holden, S., Fogarty, A., Crusz, S. A. & Diggle, S. P. (2015) Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection. Scientific Reports. 5: 7649.
Laabei, M., Jamieson, W. D., Diggle, S. P. & Jenkins, A. T. A. (2014) A new assay for rhamnolipid detection-important virulence factors of Pseudomonas aeruginosa. Applied Microbiology & Biotechnology. 98: 7199-7209.
Harrison, F., Muruli, A. Higgins, S. & Diggle, S. P. (2014) Development of an ex vivo porcine lung model for studying growth, virulence and signalling in Pseudomonas aeruginosa populations. Infection & Immunity. 82: 3312-3323.
Scott-Phillips, T., Gurney, J., Ivens, A. Diggle, S. P. & Popat, R. (2014) Combinatorial communication in bacteria: Implications for the origins of linguistic generativity. PLOS ONE. 9: e95929.
Cornforth, D. M., Popat, R., McNally, L., Gurney, J., Scott-Phillips, T., Diggle, S. P. & Brown, S. P. (2014) Combinatorial quorum sensing allows bacteria to resolve their social and physical environment. Proceedings of the National Academy of Sciences USA. 111: 4280-4284.
Allen, R. C., Popat, R., Diggle, S. P. & Brown, S. P. (2014) Targeting virulence: Can we make evolution-proof drugs? Nature Reviews Microbiology. 12: 300-308.
Ghoul, M., West, S. A., Diggle, S. P. & Griffin, A. S. (2014) An experimental test of whether cheating is context-dependent. Journal of Evolutionary Biology. 27: 551-556.
Pollitt, E. J. G., West, S. A., Crusz, S. A., Burton-Chellew, M. N. & Diggle, S. P. (2014) Cooperation, quorum sensing and the evolution of virulence in Staphylococcus aureus. Infection & Immunity. 82: 1045-1051.
Jiricny, N., Molin, S., Foster, K., Diggle, S. P., Scanlan, P. D., Ghoul, M., Santorelli, L., Popat, R., West, S. A. & Griffin, A. S. (2014) Loss of social behaviours in populations of Pseudomonas aeruginosa infecting lungs of patients with cystic fibrosis. PLOS ONE. 9: e83124.
Schuster, M., Sexton, D. J., Diggle, S. P. & Greenberg, E. P. (2013) Acyl-homoserine lactone quorum sensing: From evolution to application. Annual Review of Microbiology. 67: 43-63.
Friman, V.P., Diggle, S. P. & Buckling, A. (2013) Protist predation can favour cooperation within bacterial species. Biology Letters. 9: 20130548.
West, S. A., Winzer, K., Gardner, A. & Diggle, S. P. (2012) Quorum sensing and the confusion about diffusion. Trends in Microbiology. 20: 586-594.
Popat, R., Crusz, S. A., Messina, M., Williams, P., West, S. A. & Diggle, S. P. (2012) Quorum sensing and cheating in bacterial biofilms. Proceedings of the Royal Society B. 279: 4765-4771.
Crusz. S. A., Popat, R., Rybtke, M. T., Camara, M., Givskov, M., Nielsen, T. T., Diggle, S. P. & Williams, P. (2012) Bursting the bubble on bacterial biofilms: a flow cell methodology. Biofouling. 28: 835-842.
Youle, M., Rohwer, F., Whiteley, M., Steel, B. C., Delalez, N. J., Nord, A. L., Berry, R. M., Armitage, J. P., Kamoun, S., Hogenhout, S., Diggle, S. P., Gurney, J., Pollitt, E. J. G., Boetius, A. and Cary, S. C. (2012) The pathogen relay. In Microbial Olympics, Nature Reviews Microbiology. 10: 583-588.
Rumbaugh, K. P., Trivedi, U., Watters, C., Burton-Chellew, M., Diggle, S. P. & West, S. A. (2012) Kin selection, quorum sensing and virulence in pathogenic bacteria. Proceedings of the Royal Society B. 279: 3584-2588.
Darch, S. E., West, S. A., Winzer, K. & Diggle, S. P. (2012) Density-dependent fitness benefits in quorum sensing bacterial populations. Proceedings of the National Academy of Sciences USA. 109: 8259-8263.
Stacy, A. R., Diggle, S. P. & Whiteley, M. (2012) Rules of engagement: defining bacterial communication. Current Opinion in Microbiology. 15: 155-161.
Goldstone, R., Popat, R., Fletcher, M. P., Crusz, S. A. & Diggle, S. P. (2012) Quorum sensing and social interactions in microbial biofilms. In Microbial Biofilms: current research, methods and applications (ed. Gillian Lewis). Horizon Scientific Press.
Diggle, S. P. & Williams, P. (2012) Quorum sensing. In Brenners Encyclopedia of Genetics (ed. Maloy & Hughes).
Johansson, E. M. V., Kadam, R. U., Rispoli, G., Crusz, S. A., Bartels, K., Diggle, S. P., Cámara, M., Williams, P., Jaeger, K. E., Darbre, T. & Reymond, J. L. (2011) Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids. Medicinal Chemistry Communications. 5: 418-420.
Wilder, C. N., Diggle, S. P. & Schuster, M. (2011) Cooperation and cheating in Pseudomonas aeruginosa: the roles of the las, rhl and pqs quorum-sensing systems. ISME J. 5: 1332-1343.
Liu, X., Jia, J., Popat, R., Ortori, C. A., Li, J., Diggle, S. P., Cámara, M. & Gao, K. (2011) Characterisation of two quorum sensing systems in the endophytic Serratia plymuthica strain G3: differential control of motility and biofilm formation according to life-style. BMC Microbiology. 11: 26.
Heeb, S., Fletcher, M. P., Chhabra, S. R., Diggle, S. P., Williams, P. & Camara, M. (2011) Quinolones: from antibiotics to autoinducers. FEMS Microbiology Reviews. 35: 247-274.
Diggle, S. P., Fletcher, M. P., Camara, M. & Williams, P. (2011) Detection of 2-alkyl-4-quinolones using biosensors. Methods in Molecular Biology. 692: 21-30.
Diggle, S. P. (2010) Microbial communication and virulence: lessons from evolutionary theory. Microbiology. 156: 3503-3512.
Jiricny, N., Diggle, S. P., West, S. A., Evans, B. A., Ballantyne, G., Ross-Gillespie, A. & Griffin, A. S. (2010) Fitness correlates with the extent of cheating in a bacterium. Journal of Evolutionary Biology. 23: 738-747.
Fletcher, M. P., Heeb, S., Chhabra, S. R., Diggle, S. P., Williams, P. & Camara, M. (2010) 2-alkyl-4-quinolone signalling in Pseudomonas aeruginosa. In Pseudomonas vol VI: Molecular Microbiology, Infection & Biodiversity (ed. Alain Filloux & Juan Ramos). Springer Press.
Brown, S. P., West, S. A., Diggle, S. P., Griffin, A. S. (2009) Social evolution in microorganisms and a trojan horse approach to medical intervention strategies. Philosophical Transactions of the Royal Society B. 364: 3157-3168.
Zaborin, A., Long, J., Holbrook, C. Gerdes, S., Diggle, S. P., Rhigetti, K., Lepine, F., Wilke, A., Morozova, I., Liu, D. C., Zaborina, O. & Alverdy, J. C. (2009) Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1. Proceedings of the National Academy of Sciences USA. 106: 6327-6332.
Skindersoe, M. E., Zeuthen, L. H., Brix, S., Fink, L. N., Lazenby, J., Whittall, C., Williams, P., Diggle, S. P., Froekiaer, H., Cooley, M. & Givskov, M. (2009) Pseudomonas aeruginosa quorum sensing signal molecules interfere with dendritic cell induced T cell proliferation. FEMS Immunology and Medical Microbiology. 55: 335-345.
Rumbaugh, K. P., Diggle, S. P., Watters, C., Ross-Gillespie, A., Griffin, A. S., & West, S. A. (2009) Quorum sensing and the social evolution of bacterial virulence. Current Biology. 19: 341-345.
Johansson, E., Crusz, S. A., Kolomiets, E., Buts, L., Kadam, R. U., Cacciarini, M., Bartels, K. M., Diggle, S. P., Camara, M., Williams, P., Loris, R., Nativi, C., Rosenau, F., Jaeger, K. E., Dabre, T. & Reymond, J. L. (2008) Inhibition and dispersion of Pseudomonas aeruginosa biofilms by glycopeptide dendrimers targeting the fucose-specific lectin LecB. Chemistry and Biology. 15: 1249-1257.
Popat, R., Crusz, S. A. & Diggle, S. P. (2008) The social behaviours of bacterial pathogens. British Medical Bulletin. 87: 63-75.
Dubern, J. F. & Diggle, S. P. (2008) Quorum sensing signaling by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species. Molecular Biosystems. 4: 882-888.
von Bodman, S. B., Willey, J. M. & Diggle, S. P. (2008) Cell-to-cell communication in bacteria: united we stand. Journal of Bacteriology. 190: 4377-4391. (Review on the 3rd cell-to-cell communication in bacteria meeting held in Austin Texas in 2007).
Romero, M., Diggle, S. P., Heeb, S., Camara, M. & Otero, A. (2008) Quorum quenching activity in Anabaena sp. PCC 7120: identification of AiiC, a novel AHL-acylase. FEMS Microbiology Letters. 280: 73-80.
Diggle, S. P., West, S. A., Gardner, A. & Griffin, A. S. (2008) Communication in bacteria. In Sociobiology of communication: An interdisciplinary perspective (ed. David Hughes & Patrizia D'Ettorre): pp. 11-31. Oxford University Press.
Diggle, S. P., Heeb, S., Dubern, J. F., Fletcher, M. P., Crusz, S. A., Camara, M. & Williams, P. (2008) Quorum sensing in Pseudomonas. In Pseudomonas: Model organism, pathogen, cell factory (ed. Bernd Rehm): pp. 167-194. Wiley-VCH, Weinheim, Germany.
Diggle, S. P., Griffin, A. S., Campbell, G. S. & West S. A. (2007) Cooperation & conflict in quorum sensing bacterial populations. Nature. 450: 411-414.
Diggle, S. P., Crusz, S. A. & Camara, M. (2007) Quorum sensing. Current Biology. 17: R907-R910.
Fletcher, M. P., Diggle, S. P., Crusz, S. A., Chhabra, S. R., Camara, M. & Williams, P. (2007) A dual biosensor for 2-alkyl-4-quinolone quorum sensing signal molecules. Environmental Microbiology. 9: 2683-2693.
West, S. A., Diggle, S. P., Buckling, A. Gardner, A. & Griffin, A. S. (2007) The social lives of microbes. Annual Review of Ecology, Evolution and Systematics. 38: 53-77.
Diggle, S. P., Gardner, A., West, S. A. & Griffin, A. S. (2007) Evolutionary theory of bacterial quorum sensing: When is a signal not a signal? Philosophical Transactions of the Royal Society B. 362: 1241-1249.
Fletcher, M. P., Diggle, S. P., Camara, M. & Williams, P. (2007) Biosensor-based assays for PQS, HHQ and related 2-alkyl-4-quinolone quorum sensing signal molecules. Nature Protocols. 2: 1254-1262.
Diggle, S. P., Matthijs, S., Wright, V. J., Fletcher, M. P., Chhabra, S. R., Lamont, I. L., Kong, X., Hider, R. C., Cornelis, P., Camara, M. & Williams, P. (2007) The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multi-functional roles in quorum sensing and iron entrapment. Chemistry & Biology. 14: 87-96.
Holden, M. T. G., Diggle, S. P. & Williams, P. (2007) Quorum sensing. In Encyclopedia of Life Sciences. John Wiley & Sons.
Lumjiaktase, P., Diggle, S. P., Loprasert, S., Tungpradabkul, S., Daykin, M., Camara, M., Williams, P. & Kunakorn, M. (2006) Quorum sensing regulates dpsA and the oxidative stress response in Burkholderia pseudomallei. Microbiology. 152: 3651-3659.
Diggle, S. P., Lumjiaktase, P., Dipilato, F., Winzer, K., Kunakorn, M., Barrett, D., Chhabra, S. R., Camara, M. & Williams, P. (2006) Functional genetic analysis reveals a 2-alkyl-4-quinolone signaling system in the human pathogen Burkholderia pseudomallei and related bacteria. Chemistry & Biology. 13: 701-710.
West, S. A., Griffin, A. S., Gardner, A & Diggle, S. P. (2006) Social evolution theory for microorganisms. Nature Reviews Microbiology. 4: 597-607.
Diggle, S. P., Stacey, R. E., Dodd, C., Camara, M., Williams, P. & Winzer. K. (2006) The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa. Environmental Microbiology. 8: 1095-1104.
Sio, C. F., Otten, L. G., Cool, R. H., Diggle, S. P., Braun, P. G., Bos, R., Daykin, M., Williams, P. & Quax, W. (2006) Quorum quenching by an N-acyl homoserine lactone acylase of Pseudomonas aeruginosa PAO1. Infection & Immunity. 74: 1673-1682.
Diggle, S. P., Cornelis, P., Williams, P. & Camara, M. (2006) 4-Quinolone signalling in Pseudomonas aeruginosa: Old molecules, new perspectives. International Journal of Medical Microbiology. 296: 83-91.
Krasnogor, N., Gheorghe, M., Terrazas, G., Diggle, S. P., Williams, P. & Camara, M. (2005) An appealing computational mechanism drawn from bacterial quorum sensing. Bulletin of the European Association for Theoretical Computer Science. 83: 135-148.
Aendekerk, S., Diggle, S. P., Song, Z., Hoiby, N., Cornelis, P., Williams, P. and Camara, M. (2005) The MexGHI-OpmD multidrug efflux pump controls fitness, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication. Microbiology. 151: 1113-1125.
Terrazas, G., Krasnogor, N., Georghe, M., Bernardini, F., Diggle, S. P. & Camara, M. (2005) An environment aware P-system model of quorum sensing. In: New Computational Paradigms. Book series: Lecture Notes in Computer Science. 3526: 479-485. Springer Berlin/Heidelberg.
Westfall, L. W., Luna, A. M., Francisco, M. S., Diggle, S. P., Worrall, K. E., Williams, P., Camara, M. and Hamood, A. N. (2004) The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression. Microbiology. 150: 3797-3806.
Vallet, I., Diggle, S. P., Stacey, R. E., Camara, M., Ventre, I., Lory, S., Lazdunski, A., Williams, P. & Filloux, A. (2004) Biofilm formation in Pseudomonas aeruginosa: Fimbrial cup gene clusters are controlled by the transcriptional regulator MvaT. Journal of Bacteriology. 186: 2880-2890.
Diggle, S. P., Winzer, K., Chhabra, S. R., Worrall, K. E., Camara, M. & Williams, P. (2003) The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR. Molecular Microbiology. 50: 29-43.
Pritchard, D., Hooi, D., Watson, E., Chow, S., Telford, G., Bycroft, B., Chhabra, S. R., Harty, C., Camara, M., Diggle, S. P., & Williams, P. (2003) Bacterial quorum sensing signalling molecules as immune modulators. In Bacterial evasion of host immune responses (ed. B. Henderson & P. Oyston): pp. 201-221. Cambridge University Press.
Diggle, S. P., Winzer, K., Lazdunski, A., Williams, P. & Camara, M. (2002) Advancing the quorum in Pseudomonas aeruginosa: MvaT and the regulation of N-acylhomoserine lactone production and virulence gene expression. Journal of Bacteriology. 184: 2576-2586.
Winzer, K., Falconer, C., Garber, N. C., Diggle, S. P., Camara, M. & Williams, P. (2000) The Pseudomonas aeruginosa lectins PA-IL and PA-IIL are controlled by quorum sensing and by RpoS. Journal of Bacteriology. 182: 6401-6411.