Cystic fibrosis (CF) is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. It is characterized by the production of thick, sticky mucus that can clog the airways and trap bacteria and fungi, leading to repeated, serious lung infections. Over time, these infections can cause severe damage to the lungs. Our group is interested in how P. aeruginosa adapts to the CF lung environment and how multi-cellular aggregates increase tolerance to therapeutic interventions.