Cystic fibrosis (CF) is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. It is characterized by the production of thick, sticky mucus that can clog the airways and trap bacteria and fungi, leading to repeated, serious lung infections. Over time, these infections can cause severe damage to the lungs. Our group is interested in how P. aeruginosa adapts to the CF lung environment and how multi-cellular aggregates increase tolerance to therapeutic interventions.

Pseudomonas aeruginosa Lipid A Structural Variants Induce Altered Immune Responses.
Hofstaedter CE, O'Keefe IP, Met CM, Wu L, Vanderwoude J, Shin S, Diggle SP, Riquelme SA, Rasko DA, Doi Y, Harro JM, Kopp BT, Ernst RK.

The role of hypermutation and collateral sensitivity in antimicrobial resistance diversity of Pseudomonas aeruginosa populations in cystic fibrosis lung infection.
Vanderwoude J, Azimi S, Read TD, Diggle SP.

High prevalence of lipopolysaccharide mutants and R2-pyocin susceptible variants in Pseudomonas aeruginosa populations sourced from cystic fibrosis lung infections.
Mei M, Pheng P, Kurzeja-Edwards D, Diggle SP.

O-Specific Antigen-Dependent Surface Hydrophobicity Mediates Aggregate Assembly Type in Pseudomonas aeruginosa.
Azimi S, Thomas J, Cleland SE, Curtis JE, Goldberg JB, Diggle SP.

Heterogenous Susceptibility to R-Pyocins in Populations of Pseudomonas aeruginosa Sourced from Cystic Fibrosis Lungs.
Mei M, Thomas J, Diggle SP.

Allelic polymorphism shapes community function in evolving Pseudomonas aeruginosa populations.
Azimi S, Roberts AEL, Peng S, Weitz JS, McNally A, Brown SP, Diggle SP.

Competition in Biofilms between Cystic Fibrosis Isolates of Pseudomonas aeruginosa Is Shaped by R-Pyocins.
Oluyombo O, Penfold CN, Diggle SP.

An ex vivo lung model to study bronchioles infected with Pseudomonas aeruginosa biofilms.
Harrison F, Diggle SP.

Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection.
Darch SE, McNally A, Harrison F, Corander J, Barr HL, Paszkiewicz K, Holden S, Fogarty A, Crusz SA, Diggle SP.

Development of an ex vivo porcine lung model for studying growth, virulence, and signaling of Pseudomonas aeruginosa.
Harrison F, Muruli A, Higgins S, Diggle SP.

Loss of social behaviours in populations of Pseudomonas aeruginosa infecting lungs of patients with cystic fibrosis.
Jiricny N, Molin S, Foster K, Diggle SP, Scanlan PD, Ghoul M, Johansen HK, Santorelli LA, Popat R, West SA, Griffin AS.​