Our research Antibiotic resistance, bacteriocins, biofilms, quorum sensing, social interactions
What are we interested in? Our focus is on understanding microbial interactions and social behaviors and the implications for virulence, disease and antimicrobial resistance (AMR). Our main study organism is the antibiotic resistant superbug Pseudomonas aeruginosa (Diggle & Whiteley 2020). The CDC has identified P. aeruginosa as a 'serious threat' in healthcare settings. It is also the key pathogen in cystic fibrosis lungs and is commonly isolated from non-healing diabetic wounds.
Biofilms and Infection
P. aeruginosa assembles different aggregate types due to an interplay between environmental polymer concentration and cell surface hydrophobicity (Azimi et al. 2021).
Virulence can evolve in different directions during infection of chronic wounds (Vanderwoude et al. 2020).
We have developed an ex vivo pig lung model for studying bacterial virulence and biofilm formation in spatially structured tissue and bronchioles (Harrison et al. 2014; Harrison & Diggle 2016).
A 1000 year old recipe from an Anglo Saxon 'Leechbook' is effective at killing MRSA biofilms (Harrison et al. 2015).
Some social traits can influence the social evolution of others (Popat et al. 2017) and some traits (polysaccharides), are non-cheatable (Irie et al. 2017). Cheating is dependent upon the environmental conditions (Harrison et al. 2017).